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KMID : 1134820230520101011
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 10 p.1011 ~ p.1034
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Effects of Lamb Placenta Peptide Powder on Skin Moisturizing and Wrinkle Formation
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Lee Eun-Ji
Jang Young-Sun
Park Kyung-Won
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Abstract
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In this study, in vitro and in vivo experiments were conducted to study the effect of lamb placenta peptide powder (LPP) on skin moisturizing and wrinkle formation. Treatment with LPP significantly increased hyaluronic acid (HA) and sphingomyelin content in the UVB-irradiated HaCaT cells. A significant increase was observed in the mRNA expressions of UGTrel7, GlcNAc, elastin, fibrillin-1, LCB1 (SPT), and DEGS1, and protein expression of HAS2 in the UVB-irradiated HaCaT cells and hairless mice. In addition, exposure to LPP significantly increased the mRNA contents of TGF-βR1, procollagen type Ⅰ, and collagen type Ⅰ, and the protein expression of Smad3 in UVB-irradiated HS27 cells and mice skin tissue. Significant decreases were obtained in the protein expressions of MAPK8 (JNK), c-Fos, c-Jun, and MMPs (MMP-1, 3, 9). Furthermore, LPP treatment resulted in increased activity of SOD, CAT, and GPx and was effective in improving the formation of epidermal moisturizing, thickness, keratin, and wrinkles. Therefore, the results of this study indicate the potential benefit of LPP for skin health by inhibiting oxidative stress caused by UVB and regulating skin moisturizing and wrinkle-related signaling pathways.
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KEYWORD
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lamb placenta peptide powder, skin moisturizing, wrinkle
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